The impact of interleukin-10 ( IL-10) gene 4 polymorphisms on peripheral blood IL-10 variation and prostate cancer risk based on published studies

作者：Men, Tingting; Yu, Cuicui; Wang, Dan; Liu, Fang; Li, Jingjing; Qi, Xiaoying; Yang, Chunhua; Jiang, Wenguo; Wei, Xiaodan; Li, Xuri; Wang, Bin^*; Mi, Jia^*; Tian, Geng^*

来源：Oncotarget, 2017, 8(28): 45994-46005.

DOI：10.18632/oncotarget.17522

• prostate cancer
• interleukin-10
• polymorphism
• peripheral blood interleukin-10
• meta-analysis

This study purported to investigate the impact of interleukin-10 (IL-10) gene 4 polymorphisms (-1082G> A, -819T> C, -592A> C and 210T> C) on peripheral blood IL-10 variation and prostate cancer (PCa) risk, with a special consideration given to various origins of between-study heterogeneity. 2 researchers independently fulfilled literature retrieval, quality assessment and information collection. Sub-grouped analyses per ethnicity, continent, design type, control source, genotyping procedure, genotype validation, age-matched status, study sample size, quality score and controls' mean age were conducted, respectively. Total 17 unduplicated studies (patients/controls: 7561/8101) were assessable for PCa risk, and 4 unduplicated studies (1189 subjects) for peripheral blood IL-10 variation. Pooling all assessable studies identified a marginally significant association between the -1082A allele and increased PCa risk (odds ratio (OR)= 1.10, 95% confidence interval [CI]: 1.00 to 1.21) (Heterogeneity I-2=64.3%), and no significance was detected in sub-grouped analyses of this polymorphism. Contrastingly, the -592C allele was significantly associated with reduced PCa risk in both prospective (OR=0.85, 95% CI: 0.77 to 0.95) and population-based (OR=0.92, 95% CI: 0.84 to 1.00) studies (Heterogeneity I-2=0.0% and 18.1%). Moreover, carriers of combined -592CA/CC genotypes had a significant higher level of peripheral blood IL10 than the -592AA genotype carriers (weighted mean difference=0.45 and 0.54 mg/dL, 95% CI: 0.23 to 0.67 and 0.30 to 0.39). The above comparisons possessed a low probability of publication bias. In sum, our findings suggested that IL-10 gene -592A>C polymorphism may represent a promising candidate locus for the occurrence of PCa, and further signified a contributing role of this polymorphism in prostate carcinogenesis.

• 出版日期2017-7-11
• 单位烟台毓璜顶医院; 滨州医学院