Assessment of Intermingled Phlegm and Blood Stasis Syndrome in Coronary Heart Disease: Development of a Diagnostic Scale

作者：Zhou, Xuan; Li, Xian-tao^*; Liu, Xiao-qi; Wang, Bing; Fang, Ge

来源：Evidence-Based Complementary and Alternative Medicine, 2018, 2018: 4683431.

DOI：10.1155/2018/4683431

• TRADITIONAL CHINESE MEDICINE

Background. Intermingled Phlegm and Blood Stasis Syndrome (IPBSS) is a common feature in patients with coronary heart disease (CHD). In clinical practice, the diagnostic agreement of clinical doctor of Chinese Medicine (CM) is poor. We previously developed a IPBSS diagnostic scale for use by general practitioner. Objectives. To assess a IPBSS diagnostic scale that we previously developed for use by non-experts. Methods. This is a multicenter, prospective study involving eight study sites across China. Eligible patients were adults (>= 18 years) with CHD as demonstrated by a history of myocardial infarction, stenosis, or past coronary revascularization. IPBSS was assessed using a scale that consisted of 14 items in two domains (e.g., phlegm and blood stasis). The score range for each item was 0 to 3 points. Maximum total score was 72 points. Diagnostic accuracy was verified using consensus opinion by two independent experts as reference. Results. A total of 1,142 CHD patients were included. IPBSS was established in 729 subjects using the IPBSS diagnostic scale. In ROC curve analyses, at the optimal cut-off of 25.5, the sensitivity and specificity of the IPBSS scale were 67.6% and 72.4%, respectively. The area under the ROC curve was 0.741 (95% CI: 0.711-0.772). Conclusions. The newly developed IPBSS scoring system showed moderate performance in diagnosing IPBSS in CHD patients. Data from further large-scale diagnostic test accuracy studies are warranted.

• 出版日期2018
• 单位广州中医药大学