A rapid method for creating drug implants: Translating laboratory-based methods into a scalable manufacturing process

作者：Wang Cheng Kuo; Wang Wan Yi; Meyer Robert F; Liang Yuling; Winey Karen I; Siegel Steven J^*

来源：Journal of Biomedical Materials Research Part B: Applied Biomaterials , 2010, 93B(2): 562-572.

DOI：10.1002/jbm.b.31617

• controlled drug release
• extrusion
• implant
• poly-lactic-co-glycolic acid (PLGA)
• scanning electron microscopy (SEM)
• formulation

Low compliance with medication is the major cause of poor outcome in schizophrenia treatment While surgically implantable solvent-cast pellets were produced to improve outcome by increased compliance with medication, this process is laborious and time-consuming, inhibiting its broader application (Siegel et al, Eur J Pharm Biopharm 2006,64 287-293) In this study, the previous fabrication process was translated to a continuous and scalable extrusion method Extrusion processes were modified based on in vitro release studies, drug load consistency examination, and surface morphology analysis using scanning electron microscopy Afterward, optimized haloperidol implants were implanted into rats for preliminary analysis of biocompatibility Barrel temperature, screw speed and resulting processing pressure influenced surface morphology and drug release Data suggest that fewer surface pores shift the mechanism from bulk to surface PLGA degradation and lon

• 出版日期2010-5