Association of EPHX1 Tyr113His polymorphism with the susceptibility to lung cancer

作者：Chen, Yang; Tian, Jiyuan; Qin, Feng; Wang, Ping^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(9): 17703-17714.

• Lung cancer
• microsomal epoxide hydrolase
• EPHX1
• polymorphism

Background and objectives: Many factors have been identified as the susceptible candidates for lung cancer (LC), including EPHX1 genetic polymorphisms. Relevant researches have been carried out to explore the association between EPHX1 Tyr113His polymorphism and LC risk, but their findings were controversial rather than conclusive. Therefore, a meta-analysis was performed to systematically combine these inconsistent results. Methods: The databases of PubMed, EMBASE, BIOSIS and CNKI were searched for relevant articles. The intensity of the association between EPHX1 Tyr113His polymorphism and LC susceptibility was estimated by pooled odds ratios (ORs) with the 95% confidence intervals (95% CIs). Inter-heterogeneity was examined with Q-test, and sensitivity analysis was performed to detect whether there was any study possessing substantial impact on combined results. Publication bias among selected studies was inspected with Begg's funnel plot and Egger's test. Results: There was no significant association between EPHX1 Tyr113His polymorphism and LC susceptibility in overall analysis, but a positive relationship between them was found in Asian group after stratified analysis by ethnicity under CC vs. TT (OR=1.55, 95% CI=1.26-1.90), CC vs. TT+TC (OR=1.43, 95% CI=1.19-1.71) and C vs. T (OR=1.27, 95% CI=1.13-1.41) genetic models. Conclusion: EPHX1 Tyr113His polymorphism may be related to enhanced risk of LC in Asian populations, and this association needs to be further discussed in later studies.

• 出版日期2016
• 单位中国人民解放军第306医院; 中国人民解放军第三〇九医院