Microstructure and morphology of nimesulide/crospovidone nanocomposites by Raman and electron microscopies

作者：Bergese P^*; Alessandri I; Colombo I; Coceani N; Depero LE

来源：Composites Part A: Applied Science and Manufacturing , 2005, 36(4): 443-448.

DOI：10.1016/j.composiyesa.2004.10.006

• microstructure
• electron microscopy
• surface analysis
• polymer-drug composites

In the present work the arrangement of nanostructured nimesulide embedded inside crospovidone microparticles is experimentally studied. The analysis was carried out by observing cross-sections of the microparticles with electron and Raman microscopes. Scanning electron microscopy (SEM) gave a morphological picture of the cross-sections, energy dispersive X-ray spectroscopy (EDS) allowed to investigate the nimesulide distribution at molecular level in- and outside the crospovidone matrix, and microRaman spectroscopy (mu Raman) shed some light on the nimesulide phase composition. The drug resulted to be constrained by crospovidone into three main arrangements: an amorphous phase dispersed into the molecular cross-linked network of the polymer, nanocrystals wrapped up by the polymer, and drug layers, made of micro- and nanocrystals, segregated onto the popcorn-like surface of the polymer. According to X-ray diffraction data, the micro- and nanocrystals are highly disordered and made of crystallites with an average diameter of 17 nm.

• 出版日期2005