NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species

作者：Romero, C. A.; Grkovic, T.; Han, J.; Zhang, L.; French, J. R. J.; Kurtboke, D. I.; Quinn, R. J.^*

来源：RSC Advances, 2015, 5(126): 104524-104534.

DOI：10.1039/c5ra17553d

• IDENTIFICATION
• ANTIBIOTICS
• MOLECULES
• DISCOVERY
• TOOL

A new NMR-based method to access to the unique components of the drug-like natural product metabolome of termite-gut associated actinomycetes has been developed. This approach was used to accelerate the identification of lead-like enhanced fractions containing small molecules with unique spectral patterns. The effectiveness of the approach was demonstrated by the isolation and identification of six new natural products, namely, actinoglycosidines A (1) and B (2), actinopolymorphol D (3), niveamycin A (7), B ( 8) and C (9).

• 出版日期2015
• 单位中国科学院微生物研究所