Developmental Shifts in the Behavioral Phenotypes of Inbred Mice: The Role of Postnatal and Juvenile Social Experiences

作者：Curley J P; Rock V; Moynihan A M; Bateson P; Keverne E B; Champagne F A^*

来源：Behavior Genetics, 2010, 40(2): 220-232.

DOI：10.1007/s10519-010-9334-4

• Cross-fostering
• Maternal
• Strain differences
• Juvenile
• Social behavior
• Cross-housing

The interaction between genotype and environment is an important feature of the process of development. We investigate this interaction by examining the influence of postnatal cross-fostering and post-weaning cross-housing on the behavioral development of 129S and B6 mice. Following cross-fostering, we found significant alterations in the frequency of maternal care as a function of maternal strain and pup type as well as interactions between these variables. In adulthood, we find there are sex-specific and strain-specific alterations in anxiety-like behavior as a function of rearing environment, with males exhibiting more pronounced rearing-induced effects. Mixed-strain housing of weanlings was found to lead to alterations in home-cage social and feeding behavior as well as changes in adult anxiety-like responses of 129S mice. Anxiety-like behavior in B6 mice was altered as a function of the interaction between housing condition and weaning weight. These data illustrate the complex pathways through which early and later social experiences may lead to variations in behavior.

• 出版日期2010-3