Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro

作者:Wang, Gui-Feng; Shi, Li-Ping; Ren, Yu-Dan; Liu, Qun-Fang; Liu, Hou-Fu; Zhang, Ru-Jun; Li, Zhuang; Zhu, Feng-Hua; He, Pei-Lan; Tang, Wei; Tao, Pei-Zhen; Li, Chuan; Zhao, Wei-Min; Zuo, Jian-Ping*
来源:Antiviral Research, 2009, 83(2): 186-190.
DOI:10.1016/j.antiviral.2009.05.002

摘要

Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.