A recent bottleneck of Y chromosome diversity coincides with a global change in culture

作者：Karmin Monika; Saag Lauri; Vicente Mario; Sayres Melissa A Wilson; Jarve Mari; Talas Ulvi Gerst; Rootsi Siiri; Ilumaee Anne Mai; Maegi Reedik; Mitt Mario; Pagani Luca; Puurand Tarmo; Faltyskova Zuzana; Clemente Florian; Cardona Alexia; Metspalu Ene; Sahakyan Hovhannes; Yunu**ayev Bayazit; Hudjashov Georgi; DeGiorgio Michael; Loogvaeli Eva Liis; Eichstaedt Christina; Eelmets Mikk; Chaubey Gyaneshwer; Tambets Kristiina; Litvinov Sergei; Mormina Maru; Xue Yali

来源：Genome Research, 2015, 25(4): 459-466.

DOI：10.1101/gr.186684.114

It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.

• 出版日期2015-4