A Practical Synthesis of 1,2-Nitroamines by Michael Addition of N-Nucleophiles to Nitroalkenes

作者:Robiette Raphael*; Tran Trieu Van; Cordi Alex; Tinant Bernard; Marchand Brynaert Jacqueline
来源:Synthesis, 2010, (18): 3138-3142.
DOI:10.1055/s-0030-1258176

摘要

A practical method for the synthesis of alpha-nitroamines by Michael addition of azide to nitroalkene has been developed. This reaction proceeds in high yields under very mild conditions (phase-transfer catalysis) and is found to be general; good yields are obtained with both aryl and alkyl derivatives as well as with 1,1-disubstituted ones.

  • 出版日期2010-9