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摘要
An efficient and versatile synthesis of various congested pyridines 3a-h, 6a, b, 8a-n, 10a-g, and 16a, b, and (pyrimidin-4-yl)-acetonitriles 13a-g has been delineated by base catalyzed ring transformation of suitably functionalized 2H-pyran-2-ones 1a-h, 5, 7, and 15 by formamidine acetate 2a, acetamidine hydrochloride 2b, S-methylisothiourea 9a, pyrazol-1-yl-carboxamidine 9b, and arylamidine hydrochloride 12 separately in the presence of powdered KOH in dry DMF.
- 出版日期2007-10-8
