A new sesquiterpene lactone from Tsoongiodendron odorum Chun

作者：Song XK; Tu PF^*; Wu LJ; Cai Y; Zhu H; Lu Y; Liu XY; Zheng QT

来源：Journal of Asian Natural Products Research, 2001, 3(4): 285-291.

DOI：10.1080/10286020108040368

• Tsoongiodendron odorum Chun
• sesquiterpene lactones
• cytotoxic activity

A new sesquiterpene lactone (1) was obtained from the cytotoxic fraction of 95% ethanol extract of root barks of Tsoongiodendron odorum Chun together with two known sesquiterpene lactones, costunolide (2) and parthenolide (3). The structure of 1 was elucidated as 5 alpha, 6 alpha, 7 beta, 10 beta - 11 alpha, 13-dihydro-4(15)-eudesmene-12, 6-olide on the basis of chemical and spectral evidence including X-ray diffraction analysis. Costunolide showed cytotoxic activity against human leukemia (HL-60) cell line. Parthenolide showed promising cytotoxic activities in vitro against HCT-8, Bel-7402, SKOV3, KB, HELA and EJ cell lines. Also, the cytotoxic ethyl acetate fraction of ethanol extract of the root barks from which three chemical components were isolated showed promising cytotoxic activities in vitro against KB, BGC-823, Bel-7402, HCT-8, HL-60 cell lines.

• 出版日期2001
• 单位北京大学