A novel synthetic strategy for the stereospecific total synthesis of (+/-)-biotin

作者：Xiong Fei; Chen Xu Xiang; Liu Zhi Qian; Chen Fen Er^*

来源：Tetrahedron Letters, 2010, 51(28): 3670-3672.

DOI：10.1016/j.tetlet.2010.05.035

A concise and efficient TEA-mediated desymmetrization of meso-thioanhydride 6 with 5-ethoxy-5-oxopentylzinc bromine has been developed, which affords a convenient strategy for the stereospecific total synthesis of (+/-)-biotin 1.

• 出版日期2010-7-14
• 单位复旦大学