Pediatric Patient With Renal Cell Carcinoma Treated by Successive Antiangiogenics Drugs: A Case Report and Review of the Literature

作者:Jimenez Irene; Brisse Herve J; Freneaux Paul; Sarnacki Sabine; Michon Jean; Orbach Daniel; Pierron Gaelle; Clement Nathalie; Doz Francois; Escudier Bernard; Schleiermacher Gudrun*
来源:Journal of Pediatric Hematology/Oncology, 2017, 39(5): E279-E284.
DOI:10.1097/MPH.0000000000000774

摘要

Antiangiogenic drugs are currently standard of care in adults with renal cell carcinoma (RCC), including translocation RCC. Although antitumor activity and toxicity profile are well known in adults, few data have been reported in children. Here we present the case of a patient diagnosed at 2 years old with a metastatic translocation RCC, consecutively treated with 5 tyrosine kinase inhibitors during 6 years. The antitumor activity and toxic effects are described, and a brief review of the literature is presented.

  • 出版日期2017-7