科研之友
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摘要
Telomerase is a relevant target for cancer therapy. A small 6-mer psoralen-containing oligo-nucleotide is shown to cause efficient photo-cross-linking to human telomere DNA by G-quadruplex formation. The small, photocontrolled oligonucleotide shows effective telomerase inhibition, both in vitro and in vivo, only when light irradiated. Data suggest that it is a promising agent for the treatment of cancer.
- 出版日期2010-1-20
