Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir

作者：Collins Jeffrey M^*; Raphael Kara Loren; Terry Charles; Cartwright Emily J; Pillai Anjana; Anania Frank A; Farley Monica M

来源：Clinical Infectious Diseases, 2015, 61(8): 1304-1306.

DOI：10.1093/cid/civ474

• HBV/HCV coinfection
• HBV reactivation
• acute hepatitis
• sofosbuvir
• simeprevir

Treatment of hepatitis C virus with potent, interferon-free, direct-acting antiviral regimens with no activity against hepatitis B virus (HBV) may increase the risk for HBV reactivation in coinfected patients. We present 2 cases of HBV reactivation during treatment with an all-oral regimen of simeprevir and sofosbuvir and discuss strategies to prevent HBV flare.

• 出版日期2015-10-15