Antiangiogenic and radiotherapy for cancer treatment

作者：Kobayashi H; Lin P C^*

来源：Histology and Histopathology, 2006, 21(10): 1125-1134.

• angiogenesis
• ionizing radiation
• endothelial cell
• VEGF and angiogenic growth factor

Tumor growth and progression depends on tumor angiogenesis, the growth of tumor blood vessels, therefore, targeting tumor angiogenesis is a very promising approach for controlling tumor growth and/or causing regression. Tumor blood vessels have been recognized as a critical component of radiation response to the point of being independent of tumor oxygenation during radiation. An anti-angiogenic approach has been considered less likely to develop drug resistance. But recent findings suggest that anti-angiogenesis causes hypoxia that selects tumor cells (due to genetic instability) that are less dependent on blood supply and leads to drug resistance. The approach of combination of anti-angiogenesis with ionizing radiation by targeting both endothelial and tumor cells should minimize this possibility. The combination may produce a synergistic anti-tumor effect.

• 出版日期2006-10