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摘要
An efficient tandem process for the synthesis of pyridoimidazo-fused beta-carbolines: pyrido[2",1":2'3'] imidazo [4',5':2,3]pyrido[4,5-b]indole, is described. The construction of these compounds was achieved by one-pot three component reaction of 1-benzy1-1H-indole-3-carbaldehyde, 2-aminopyridine and trimethylsilyl cyanide via Groebke-Blackburn-Bienayme reaction, followed by cyclization through the Pictet-Spengler reaction of the resulting imidazo[1,2-a]pyridine which allowed access to the title heterocycles.
- 出版日期2017-2-1
- 单位渤海大学
