ABC transporters: consequences of interaction with flavonoids

作者：Alvarez De Felipe Ana I; Pulido Duarte Mivis M

来源：Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 2008, 7(6): 296-311.

• P-glycoprotein
• Breast Cancer Resistance Protein (BCRP)
• Multidrug Resistance Protein 1 (MRP1)
• Multidrug Resistance Protein 2 (MRP2)
• Flavonoids
• Efflux

The ATP-binding cassette (ABC) transporters constitute one of the largest protein families widely distributed and evolutionarily conserved which are involved in detoxifying and transport processes. Mainly they efflux metabolites and toxins and protect and benefit the cell function. They are characterized by the wide substrate specificity being responsible for the active secretion of several drugs some of them with therapeutic relevance in cell targets. This transport could be the origin of multidrug resistance (MDR) in some cases. The knowledge of these proteins is relevant in order to optimize cancer therapies or toxin elimination. Flavonoids are an integral component of our common diet. They are found in fruits, vegetables, teas, wine and beer. Their intake has been associated with lesser risk of some types of cancer, cardiovascular diseases, osteoporosis and age-related degenerative diseases. All these health promoting effects had increased dramatically its consumption. Flavonoids interact with ABC transporters as substrate or inhibitor compounds; in addition they could be involved in controlling the gene expression of some of them. This interaction might have important consequences affecting drug treatment itself and multidrug resistance with special relevance regarding toxin removal. This review will show and discuss the current literature regarding flavonoids and ABC transporters such as P-glycoprotein, MRPs and BCRP/ABCG2

• 出版日期2008