Blood-brain barrier peptide shuttles

作者:Sanchez Navarro Macarena; Giralt Ernest; Teixido Meritxell
来源:Current Opinion in Chemical Biology, 2017, 38: 134-140.
DOI:10.1016/j.cbpa.2017.04.019

摘要

Brain delivery is hampered by the presence of the blood-brain barrier (BBB), a natural defence of the brain that protects it and allows the entrance of nutrients by several mechanisms. Taking advantage of these mechanisms is an opportunity to treat brain related diseases. Among the different alternatives, BBB peptide shuttles are gaining attention to increase brain delivery of therapeutics. The most recent advances in the field are analysed here.

  • 出版日期2017-6