Nafion-H-A (R)-catalyzed synthesis of polyhydroquinolines via the Hantzsch multicomponent reaction

作者:Kidwai Mazaahir*; Chauhan Ritika; Bhatnagar Divya; Singh Abhay K; Mishra Biswajit; Dey Sharmistha
来源:Monatshefte fur Chemie, 2012, 143(12): 1675-1680.
DOI:10.1007/s00706-012-0742-4

摘要

A facile and efficient one-pot, four-component synthesis of polyhydroquinoline derivatives via the Hantzsch reaction using Nafion-H-A (R) as heterogeneous catalyst in PEG 400-water solvent system is described herein. The present methodology offers several advantages such as excellent yields, simple procedure, shorter reaction times, and milder conditions with remarkable recyclability.