Differential expression of KCNQ1 K+ channel in tubular cells of frog kidney

作者：Cirovic S; Markovic Lipkovski J^*; Todorovic J; Nesovic Ostojic J; Jovic M; Ilic S; Tatic S; Cemerikic D

来源：European Journal of Histochemistry, 2010, 54(1): 35-38.

DOI：10.4081/ejh.2010.e7

• KCNQ1 K+ channel
• rana esculenta
• frog kidney
• immunohistochemistry

The aim of this study was to evaluate KCNQ1 K+ channel expression in the frog kidney of Rana esculenta KCNQ1 K+ channel, also known as KvLQT1, is the pore forming alpha-subunit of the I-Ks K+ channel, a delayed rectifier voltage-gated K+ channel, which has an important role in water and salt transport in the kidney and gastrointestinal tract The expression of KCNQ1 K+ channel along tubular epithelium differs from species to species In the present study the expression of KCNQ1 K+ channel in the frog kidney has been demonstrated by immunohistochemistry The presence of KCNQ1 K+ channel was demonstrated in the epithelial cells of distal convoluted tubule and collecting duct. However, the pattern of expression of KCNQ1 K+ channel differs between distal convoluted tubules and collecting duct All epithelial cells of distal convoluted tubules revealed basolateral expression of KCNQ1 K+ channel On the contrary, only the single cells of collecting duct, probably intercalated cells, showed diffuse cell surface staining with antibodies against KCNQ1 K+ channel These findings suggest that KCNQ1 K+ channel has cell-specific roles in renal potassium ion transport.

• 出版日期2010-3
• 单位中国人民解放军军事医学科学院