Diversity of IL-17-producing T lymphocytes

作者：Kim Jiyeon S; Jordan Martha S^*

来源：Cellular and Molecular Life Sciences, 2013, 70(13): 2271-2290.

DOI：10.1007/s00018-012-1163-6

• Cytokine
• Th17 cells
• nTh17 cells
• gamma delta T cells
• iNKT cells
• Host defense
• Autoimmunity

Interleukin (IL)-17 is a pro-inflammatory cytokine that plays critical roles in host defense against extracellular bacteria and fungi and also in the pathogenesis of autoimmune diseases. While CD4+ TCR alpha beta+ T helper (Th) 17 cells are the best-described cellular source of IL-17, many innate-like T cells are in fact potent producers of IL-17. Given the increasing interest in therapeutic modulation of the IL-17 axis, it is crucial to better understand the cellular origins of IL-17 in various infection and diseases settings. While the diverse population of IL-17-producing T cells share many common characteristics, notable differences also exist. In this review, we discuss the heterogeneity of IL-17-producing T cell types focusing on their development, regulation, and function.

• 出版日期2013-7