A nuclear magnetic resonance approach to the comparison of mucoadhesive properties of polysaccharides for ophthalmic uses

作者：Uccello Barretta Gloria^*; Nazzi Samuele; Balzano Federica; Sanso Marco

来源：International Journal of Pharmaceutics, 2011, 406(1-2): 78-83.

DOI：10.1016/j.ijpharm.2010.12.032

• Nuclear magnetic resonance
• Polymer interaction
• Mucoadhesion
• Eye-drop excipient

Mucoadhesive properties of tamarind seed polysaccharide (TSP) and larch arabinogalactan (AG), which are developed for ophthalmic applications, were investigated by NMR spectroscopy. Polysaccharide to mucin affinities were compared by using ketotifen fumarate as low molecular weight interaction probe. Proton selective relaxation rate measurements revealed enhanced affinity of TSP to mucin with respect to AG.

• 出版日期2011-3-15