科研之友
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摘要
In the presence of In/CuCl, ethyl 4-bromo-4,4-difluoro-3-oxo-2-(triphenylphosphoranylidene)butanoate reacted with various aldehydes in aqueous medium at room temperature to give the alpha,alpha-difluorinated beta-hydroxy carbonyl compounds. Furthermore, treating Reformatsky addition compounds with 1 equiv. of sodium hydroxide in the mixture of tetrahydrofuran and water afforded gem-difluoromethylenated 2-triphenylphosphoranylidene delta-lactones in excellent yields.
