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摘要
The notion that nuclear factor-kappa B (NF-kappa B) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-kappa B in carcinogenesis and tumorigenesis. Although the tumor suppressor-like effect of NF-kappa B remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-kappa B activation as a broad strategy in treating cancers.
- 出版日期2007-12-1
- 单位国家安全生产监督管理总局信息研究院
