A novel hydrogen bonded bimetallic supramolecular coordination polymer {[SnMe3(bpe)][Ag(CN)(2)]center dot 2H(2)O} as anticancer drug

作者：Etaiw Safaa El din H^*; Sultan Ahmed S; El din Ahmed S Badr

来源：European Journal of Medicinal Chemistry, 2011, 46(11): 5370-5378.

DOI：10.1016/j.ejmech.2011.08.041

• Silver cyanide
• Trimethyltin
• 1,2-Bis(4-pyridyl)ethane
• Supramolecular coordination polymer
• Hydrogen bonds
• Fluorescence
• Antitumor activity

The reaction of Me3SnCl, K-3[Ag(CN)(4)] and 1,2-bis(4-pyridyl)ethane (bpe) in water/CH3CN solution at room temperature affords the novel bimetallic supramolecular coordination polymer (SCP) {[SnMe3(bpe)] [Ag(CN)(2)]center dot 2H(2)O}(n), 1. The structure of 1 consists of cationic {-Sn(Me-3)-bpe-)(+) chains that are neutralized by [Ag(CN)(2)](-) anions. The dicyanoargentate(1) anions present discrete uncoordinated fragments between the cationic chains. The water molecules bind the cationic chains and the anions forming 3D-supramolecular structure through hydrogen bonds. 1 exhibits strong fluorescence in the solid state at room temperature. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MU) assay was used to determine the in vitro antitumor effects of the SCP 1 on human breast cancer cell line, T-47D. Cell cycle analysis revealed that the SCP 1 induced apoptosis in T-47D breast cancer cell line. Moreover, in vivo, the SCP 1 showed tumor growth inhibition in rat model that developed mammary carcinoma by 44.8% compared to the vehicle treated control. Thus, the SCP 1 exhibits specific in vivo and in vitro antitumor effects.

• 出版日期2011-11