Attenuation of Urinary Cadmium in Inhabitants of the Environmentally Exposed Jinzu River Basin Determined by Applying a Mixed Linear Model

作者：Nogawa Kazuhiro; Suwazono Yasushi^*; Ishizaki Masao; Aoshima Keiko; Okamoto Rie; Nishijo Muneko; Nakagawa Hideaki; Kido Teruhiko

来源：Bulletin of Environmental Contamination and Toxicology, 2016, 96(5): 699-703.

DOI：10.1007/s00128-016-1768-9

• Cadmium
• Biological half-life
• Longitudinal study
• Risk assessment
• Human

Half-life of urinary cadmium level (U-Cd) was estimated in inhabitants whose initial U-Cd was a parts per thousand yen5 mu g/L (131 men and 177 women) or a parts per thousand yen5 mu g/gcr (195 men and 246 women), using a linear mixed model adjusted for the baseline age. To clarify the effect of initial U-Cd, the target participants were divided into higher or lower initial U-Cd group. In the higher groups, the half-lives were 15.4 and 13.1 years for unadjusted U-Cd and 19.0 and 23.0 years for creatinine-adjusted U-Cd, in men and women, respectively. In the lower groups, the half-lives were 38.0 and 26.0 years for unadjusted U-Cd in men and women. For creatinine-adjusted U-Cd, it was 42.9 years in men. For attenuation of U-Cd, there were an early fast component shown in the higher group and late slow component shown in the lower group. The attenuation of U-Cd is slower in the longer time compared to that previously reported.

• 出版日期2016-5