A novel synthetic strategy for monosubstituted cyclodextrin derivatives

作者:Di Fabio Giovanni*; Malgieri Gaetano; Isernia Carla; D' Onofrio Jennifer; Gaglione Maria; Messere Anna; Zarrelli Armando; De Napoli Lorenzo
来源:Chemical Communications, 2012, 48(32): 3875-3877.
DOI:10.1039/c2cc30550j

摘要

A first solid phase approach to obtain monosubstituted CD conjugates to different labels has been developed. A new solid support has been designed to get a variety of C-6 monofunctionalized CDs (alpha, beta, Me beta CD and HP beta CD) covalently linked through a phosphodiester bridge to different labels, in highly pure form and under very mild detachment conditions.