Schisanwilsonins A-G and related anti-HBV lignans from the fruits of Schisandra wilsoniana

作者：Ma, Wen-Hui; Lu, Yan; Huang, Hai; Zhou, Pei; Chen, Dao-Feng^*

来源：Bioorganic & Medicinal Chemistry Letters, 2009, 19(17): 4958-4962.

DOI：10.1016/j.bmcl.2009.07.078

• Schisandra wilsoniana
• Schisanwilsonin
• Anti-HBV
• Lignan

Seven new dibenzocyclooctane lignans, schisanwilsonins A-G (1-7), were isolated from the fruits of Schisandra wilsoniana, together with five known lignans (8-12). The structures of these new compounds were elucidated by spectroscopic methods including 2D-NMR techniques. The 12 lignans were tested for anti-hepatitis B virus (HBV) activity in vitro. Schisanwilsonin D ( 4), schisantherin C (9), deoxyschizandrin (10) and (+)-gomisin K-3 (11) showed anti-HBV activity. 9 exhibited the most potent anti-HBV activity with potency against HBsAg and HBeAg secretion by 59.7% and 34.7%, respectively, at 50 mu g/mL.

• 出版日期2009-9-1
• 单位复旦大学