Dimethylarsinic acid effects on DNA damage and oxidative stress related biochemical parameters in B6C3F1 mice

作者：Ahmad S; Anderson WL; Kitchin KT^*

来源：Cancer Letters, 1999, 139(2): 129-135.

DOI：10.1016/S0304-3835(99)00022-1

• dimethylarsinic acid
• DNA damage
• oxidative stress
• B6C3F1 mice

Adult female B6C3F1 mice were given 720 mg/kg of DMA by oral gavage at one of three times (2 h, 15 h, or at both 21 and 4 h) before sacrifice. Significant (P < 0.05) decreases in liver GSH and GSSG contents (15-37%) were observed. Some evidence of DMA-induced hepatic DNA damage (at the P < 0.10 level only) was observed. Pulmonary and hepatic ODC activities were reduced (19-59%) by DMA treatment. Overall, these biochemical studies show that mice are much less responsive to DMA than rats.

• 出版日期1999-5-24