A new embelin from the mangrove Aegiceras corniculatum

作者：Thota Satya Prakasa Rao; Sarma Nittala S^*; Murthy Y L N; Kantamreddi V S S N; Wright C W

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2016, 55(1): 123-127.

• Aegiceras corniculatum
• quinonoids
• antimalarial activity

One new compound (2) and five known compounds (1, 3-6) have been isolated from the mangrove plant Aegiceras corniculatum collected from the Godavari mangrove forest, India. The structure of the new compound has been established by H-1 and C-13 NMR spectroscopy and mass spectral data as 2,5-didehydroxy-6-methylembelin (2). The known compounds have been characterized as 4-hydroxy-2-methoxybenzamide (1), embelin (3), 5-O-ethylembelin (4), 5-O-methylembelin (5) and 4-methoxyresorcinol (6). Compounds 2-5 exhibit moderate antimalarial activity. Embelin (3) shows activity against chloroquine-resistant strains better than against chloroquine-sensitive strains of Plasmodium falciparum.

• 出版日期2016-1