Secoemestrin D, a Cytotoxic Epitetrathiodioxopiperizine, and Emericellenes A-E, Five Sesterterpenoids from Emericella sp AST0036, a Fungal Endophyte of Astragalus lentiginosus

作者：Xu Ya ming; Espinosa Artiles Patricia; Liu Mangping X; Arnold A Elizabeth; Gunatilaka A A Leslie^*

来源：Journal of Natural Products, 2013, 76(12): 2330-2336.

DOI：10.1021/np400762k

A new epitetrathiodioxopiperizine, secoemestrin D (1), and five sesterterpenoids bearing anew carbon skeleton, emericellenes A-E (2-6), together with previously known fungal metabolites, sterigmatocystin (7), arugosin C (8), and epiisoshamixanthone (9), were obtained from the endophytic fungal strain Emericella sp. AST0036 isolated from a healthy leaf tissue of Astragalus lentiginosus. The planar structures and relative configurations of the new metabolites 1-6 were elucidated using MS and 1D and 2D NMR spectroscopic data. All compounds were evaluated for their potential anticancer activity using a panel of six tumor cell lines and normal human fibroblast cells. Only metabolites 1 and 7 showed cytotoxic activity. More importantly, secoemestrin D (1) exhibited significant cytotoxicity with IC50 values ranging from 0.06 to 0.24 mu M and moderate. selectivity to human glioma (SF-268) and metastatic breast adenocarcinoma (MDA-MB-231) cell lines.

• 出版日期2013-12