A New Synthesis of 2,3-Di- or 2,3,3-Trisubstituted 2,3-Dihydro-4-pyridones by Reaction of 3-Ethoxycyclobutanones and N-p-Toluenesulfonyl Imines Using Titanium(IV) Chloride: Synthesis of (+/-)-Bremazocine

作者：Matsuo Jun ichi^*; Okado Ryohei; Ishibashi Hiroyuki

来源：Organic Letters, 2010, 12(14): 3266-3268.

DOI：10.1021/ol1012313

N-p-Toluenesulfonyl (Ts) aldimines reacted with 3-ethoxycyclobutanones by catalysis of titanium(IV) chloride to afford 2,3-di- or 2,3,3-trisubstituted N-Ts-2,3-dihydro-4-pyridones. Synthesis of (+/-)-bremazocine was efficiently accomplished by using this method.

• 出版日期2010-7-16
• 单位河北医科大学