A straightforward enantioselective synthesis of F17807

作者：Alliot Julien; Gravel Edmond; Buisson David Alexandre; Larquetoux Laurent; Nicolas Marc; Doris Eric^*

来源：Tetrahedron, 2015, 71(50): 9383-9387.

DOI：10.1016/j.tet.2015.10.065

• Benzodioxane
• SNAr
• Mitsunobu
• Enantioselective synthesis

An efficient approach for the enantioselective synthesis of the 1,4-benzodioxane F17807 drug is reported. The developed route relied on two key steps, namely SNAr and Mitsunobu reactions, which permitted a straightforward access to the title compound with full preservation of the enantiomeric excess throughout the synthetic sequence.

• 出版日期2015-12-16
• 单位中国地震局