Membrane-mediated actions of 1,25-dihydroxy vitamin D3: A review of the roles of phospholipase A(2) activating protein and Ca2+/calmodulin-dependent protein kinase II

作者：Doroudi Maryam; Schwartz Zvis; Boyan Barbara D^*

来源：Journal of Steroid Biochemistry and Molecular Biology, 2015, 147: 81-84.

DOI：10.1016/j.jsbmb.2014.11.002

• 1 alpha,25(OH)(2)D-3
• PDIA3
• PLA(2)
• PLAA
• Protein kinase C
• Ca2(+)/calmodulin-dependent protein kinase II

The secosteroid 1 alpha,25-dihydroxy vitamin D3 [1 alpha,25(OH)(2)D-3] acts on cells via classical steroid hormone receptor-mediated gene transcription and by initiating rapid membrane-mediated signaling pathways. In its membrane-initiated pathway, after 1 alpha,25(OH)(2)D-3 interacts with protein disulfide isomerase, family A, member 3 (Pdia3) in caveolae, phospholipase A(2) (PLA(2)) and protein kinase C (PKC) are activated. Recent efforts to determine the signaling proteins involved in the 1 alpha,25(OH)(2)D-3 signal from Pdia3 to PLA(2) have indicated that phospholipase A(2) activating protein (PLAA) and Ca2+/calmodulin-dependent kinase II (CaMKII) are required. PLAA is located in caveolae, where it interacts with Pdia3 and caveolin-1 (Cav-1) to initiate rapid signaling via CaMKII, activating PLA(2), leading to activation of protein kinase C (PKC) and PKC-dependent responses.

• 出版日期2015-3