METABOLISM Cancer mistunes methylation

作者:Shlomi Tomer*; Rabinowitz Joshua D
来源:Nature Chemical Biology, 2013, 9(5): 293-294.
DOI:10.1038/nchembio.1234

摘要

Metabolic aberrations affecting protein and DNA methylation are a potential source of cancer. A new study shows that the metabolic enzyme nicotinamide N-methyl-transferase, which is overexpressed in several types of tumors, can enhance cancer aggressiveness by draining methyl groups from S-adenosyl-methionine.

  • 出版日期2013-5