Multigram synthesis of a water-soluble porphyrazine and derived seco-porphyrazine labeling agents

作者：Guinchard Xavier; Fuchter Matthew J; Ruggiero Andrea; Duckworth Brian J; Barrett Anthony G M^*; Hoffrnan Brian M

来源：Organic Letters, 2007, 9(25): 5291-5294.

DOI：10.1021/ol702481x

Porphyrazine III has been synthesized on a large scale (18.4 g), with minimal chromatographic purification by employing a novel one-pot, 3-step sequence. Two dinitrile precursors I and II, the latter of which consisted of a mixture of geometric isomers, were transformed, via the corresponding pyrroline diimines, into a mixture of III and the octa-Ar(1)-porphyrazine. Isolated macrocycle III was subsequently transformed into IV, a water-soluble seco-porphyrazine suitable for the labeling of biological vectors.

• 出版日期2007-12-6
• 单位西北大学