Developing a unique metal-organic framework-{[Cd(abtz)(2)(NCS)]center dot.(ClO4)}(n) (abtz=1-(4-aminobenzyl)-1,2,4-triazole) as fluorescent probe for highly selective and sensitive detection of ascorbic acid in biological liquid

作者：Guo, Chao; Jin, Qing; Wang, Youyou; Ding, Bin^*; Li, Yan^*; Huo, Jianzhong; Zhao, Xiaojun

来源：Sensors and Actuators B: Chemical , 2016, 234: 184-191.

DOI：10.1016/j.snb.2016.04.128

• Metal-organic frameworks
• Fluorescent probe
• Ascorbic acid
• Biological liquid

Nowadays metal-organic frameworks (MOFs) have aroused great interest because of their fascinating tunable structures and unusual functional properties. In the recent years, MOFs have been used as new sensing materials to effectively detect cations, anions and nitroaromatic complexes due to their high selectivity and good sensitivity. In this work, we explored a unique fluorescent metal-organic framework {[Cd(abtz)(2)(NCS)]center dot(ClO4)}(n) (MOF-Cd-abtz; abtz = 1-(4-aminobenzyl)-1,2,4-triazole) for highly selective and sensitive detection of ascorbic acid in biological liquid (such as human urine and serum samples). Because both the fluorescent material MOF-Cd-abtz and ascorbic acid can absorb the excitation light at 250 nm, thereby ascorbic acid can quantitatively quench fluorescent signals of MOF-Cd-abtz in biological liquid. This MOF-Cd-abtz based fluorescent method exhibits good liner response to ascorbic acid in the range of 0.1-140 mu M. The relative standard deviation (RSD) for three times replicate detections of 25 mu M ascorbic acid was 0.94%, and the detection limit was 75 nM (S/N=3). The developed method can be applied for the determination of ascorbic acid in human urine and serum samples with quantitative spike recoveries from 93% to 103%.

• 出版日期2016-10-29
• 单位天津师范大学