A new, one-pot, multicomponent synthesis of 5-aza-9-deaza-adenines under microwave irradiation

作者：Lim Felicia Phei Lin; Luna Giuseppe; Dolzhenko Anton V^*

来源：Tetrahedron Letters, 2014, 55(37): 5159-5163.

DOI：10.1016/j.tetlet.2014.07.105

• Purine analogue
• Pyrazole
• Triazine
• Multicomponent reaction
• Cyanamide

A new, practical, three-component method for the synthesis of 5-aza-9-deaza-adenines is developed. Aminopyrazoles react in a one-pot fashion with triethyl orthoformate and cyanamide under microwave irradiation affording 5-aza-9-deaza-adenines in good yields and high purity. The main advantages of this method are the operational simplicity, accessibility, and high efficiency.

• 出版日期2014-9-10