Ultra-deep sequencing provides insights into the virology of hepatitis C super-infections in a case of three sequential infections with different genotypes

作者：Chung Emily; Ferns R Bridget; He Miao; Rigatti Roberto; Grant Paul; McCormick Adele; Bhagani Sanjay; Webster Daniel Peter; Nastouli Eleni^*; Waters Laura Jane

来源：Journal of Clinical Virology, 2015, 70: 63-66.

DOI：10.1016/j.jcv.2015.06.105

• Hepatitis C
• HIV
• Ultra-deep sequencing
• Super-infection
• Genotype

The current epidemic of Hepatitis C infection in HIV-positive men who have sex with men is associated with increasing use of recreational drugs. Multiple HCV infections have been reported in haemophiliacs and intravenous drug users. Using ultra-deep sequencing analysis, we present the case of an HIV-positive MSM with evidence of three sequential HCV infections, each occurring during the acute phase of the preceding infection, following risk exposures. We observed rapid replacement of the original strain by the incoming genotype at subsequent time points. The impact of HCV super-infection remains unclear and UDS may provide new insights.

• 出版日期2015-9