A comparison of copper and acid site zeolites for the production of nitric oxide for biomedical applications

作者：Russell Samantha E^*; Carballo Juan Maria Gonzalez; Orellana Tavra Claudia; Fairen Jimenez David; Morris Russell E^*

来源：Dalton Transactions, 2017, 46(12): 3915-3920.

DOI：10.1039/c7dt00195a

Copper-exchanged and acidic zeolites are shown to produce nitric oxide (NO) from a nitrite source in biologically active (nanomolar) concentrations. Four zeolites were studied; mordenite, ferrierite, ZSM-5 and SSZ-13, which had varying pore size, channel systems and Si/Al ratios. ZSM-5 and SSZ-13 produced the highest amounts of NO in both the copper and acid form. The high activity and regeneration of the copper active sites makes them good candidates for long-term NO production. Initial cytotoxicity tests have shown at least one of the copper zeolites (Cu-SSZ-13) to be biocompatible, highlighting the potential usage within biomedical applications.

• 出版日期2017-3-28