Anti-diabetic and anti-oxidant status of Loranthus pulverulentus obtained from two different hosts

作者：Kamran Sairah Hafeez^*; Ahmad Mobasher; Shahwar Durre; Ajaib Muhammad

来源：Bangladesh Journal of Pharmacology, 2016, 11(1): 181-189.

DOI：10.3329/bjp.v11i1.24056

Leaves of Loranthus pulverulentus have been used ethnically in Pakistan for controlling blood glucose levels. The present study was designed to investigate the anti-diabetic and anti-oxidant potential of the methanolic extracted fractions of L. pulverulentus obtained from two different hosts' viz. Dalbergia sissoo and Populus nigra. The acute study demonstrated that L. pulverulentus (D. sissoo) leaves possess significant blood glucose lowering effect whereas L. pulverulentus (P. nigra) was didn't significantly decreased blood glucose levels. The n-butanol fraction of L. pulverulentus (D. sissoo) also significantly increased in vivo total anti-oxidant activity on eighth day after treatment and blood glucose levels were significantly reduced (%46.7) when compared to the control diabetic group (%. up arrow 198.1) and metformin treated group (% up arrow 25.9). Leaves of L. pulverulentus (D. sissoo) have good margin of safety as therapeutic index is 3.5. This study provides scientific evidence that leaves of L. pulverulentus (D. sissoo) possess potential anti-diabetic activity whereas L. pulverulentus (P. nigra) was not found effective in diabetic illness.

• 出版日期2016