Anabolic-androgenic steroids and appetitive sexual behavior in male rats

作者：Kim Jessica Y; Wood Ruth I^*

来源：Hormones and Behavior, 2014, 66(4): 585-590.

DOI：10.1016/j.yhbeh.2014.08.009

• Anabolic agents
• Androgen
• Food reward
• Operant behavior
• Sexual behavior, animal

Anabolic-androgenic steroids (AAS) increase libido and sexual behavior, but the underlying behavioral mechanisms are unclear. One way MS may enhance expression of sexual behavior is by increasing the willingness to work for sex. In the present study, sexually-experienced male rats received daily injections of testosterone at supraphysiologic doses (7.5 mg/kg in water with 13% cydodextrin) or vehicle and were tested for appetitive sexual behavior measured by operant responding for access to an estrous female. Initially, rats were trained in their home cage to respond on a nose-poke under a 10-min fixed-interval schedule for food reward. Once rats achieved stable response rates, the food was replaced by a female, followed by mating for 10 min. There was no effect of testosterone on operant responding for food (28.1 +/- 4.4 responses/10 min for testosterone, 30.6 +/- 43 for vehicle) or sex (35.0 +/- 4.0 responses/10 min for testosterone, 37.3 +/- 5.2 for vehicle). However, rats made significantly more responses for sex than for food (p < 0.05), and responses for food and sex were positively correlated among individuals (R-2 = 0.6). Additional groups of rats were trained to respond on a lever for the female under a 2nd-order schedule of reinforcement, where 5 responses opened a door to show the female for 5 s. After 15 door openings, the male gained access to the female. There was no effect of testosterone on time to complete 75 responses: 38.4 +/- 7.8 min for vehicle controls vs 43.3 +/- 6.6 min for testosterone-treated rats (p > 0.05). These findings suggest that chronic high-dose testosterone does not enhance appetitive drive for sexual behavior.

• 出版日期2014-9