科研之友
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摘要
Isolated aromatic interactions in designed octapeptide -hairpin scaffolds display a near-universal T-shaped face-to-edge geometry in all positional permutations, with the exception of aryl-Trp interactions. The heterogeneous asymmetric indole ring of Trp competes for a shielding face geometry, which lowers the scaffold stability in FtE aryl-Trp pairs. Assessment of the contributions of aryl pairs (in the absence of solvent-driven interactions) to the overall -hairpin structure reveals the superiority of Trp-Phe and Trp-Tyr contributions over the well-established scaffold stabilization by Trp-Trp.
- 出版日期2014-11-3
