Medicinal Flowers. XXVII. New Flavanone and Chalcone Glycosides, Arenariumosides I II, III, and IV, and Tumor Necrosis Factor-alpha Inhibitors from Everlasting, Flowers of Helichrysum arenarium

作者：Morikawa Toshio; Wang Li Bo; Nakamura Seikou; Ninomiya Kiyofumi; Yokoyama Eri; Matsuda Hisashi; Muraoka Osamu; Wu Li Jun; Yoshikawa Masayuki^*

来源：CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57(4): 361-367.

DOI：10.1248/cpb.57.361

• Helichrysum arenarium
• arenariumoside
• medicinal flower
• tumor necrosis factor-alpha inhibitory activity
• Asteraceae
• everlasting

The methanolic extract from the flowers of Helichrysum arenarium L. MOENCH was found to show inhibitory effect on tumor necrosis factor-alpha (TNF-alpha 1 ng/ml)-induced cytotoxicity in L929 cells. From the methanolic extract, 50 constituents including four new flavanone and chalcone glycosides named arenariumosides I (1), II (2), III (3), and IV (4) were isolated. The stereostructures of 1-4 were elucidated on the basis of chemical and physicochemical evidence. Among the constituents, naringenin 7-O-beta-D-glucopyranoside (7), apigenin 7-O-beta-D-glucopyranoside (14), apigenin 7-O-gentiobioside (16), and apigenin 7,4'-di-O-beta-D-glucopyranoside (17) significantly inhibited TNF-alpha-induced cytotoxicity in L929 cells at 30 mu m.

• 出版日期2009-4
• 单位沈阳药科大学