An expedient synthesis of spirooxindoles incorporating 2-amino pyran-3-carbonitrile unit employing dialkyl acetone-1,3-dicarboxylates

作者：Satheesh Monisha; Balachandran Aswathy L; Devi Parvathi R; Deepthi Ani^*

来源：Synthetic Communications, 2018, 48(5): 582-587.

DOI：10.1080/00397911.2017.1416143

• 2-Amino pyran-3-carbonitrile
• dialkyl 1
• 3-acetone dicarboxylates
• isatilidenes
• spirooxindoles
• tricarbonyl compounds

Spirooxindoles are a class of molecules possessing significant biological effects such as antiviral, antifungal, antibacterial and anticancer properties. Herein we report a series of spirooxindole molecules having 2-amino pyran-3-carbonitrile and with two ester groups. These molecules were prepared by the reaction of dialkyl acetone-1,3-dicarboxylate and isatilidenes in the presence of triethyl amine.
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• 出版日期2018