Adventitial Vasa Vasorum Arteriosclerosis in Abdominal Aortic Aneurysm

作者：Tanaka Hiroki; Zaima Nobuhiro; Sasaki Takeshi; Hayasaka Takahiro; Goto Inoue Naoko; Onoue Kenji; Ikegami Koji; Morita Yoshifumi; Yamamoto Naoto; Mano Yuuki; Sano Masaki; Saito Takaaki; Sato Kohji; Konno Hiroyuki; Setou Mitsutoshi^*; Unno Naoki

来源：PLos One, 2013, 8(2): e57398.

DOI：10.1371/journal.pone.0057398

Abdominal aortic aneurysm (AAA) is a common disease among elderly individuals. However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV) to deliver oxygen and nutrients to the aortic wall. In this study, we examined changes in the adventitial VV wall in AAA to clarify the histopathological mechanisms underlying AAA. We found marked intimal hyperplasia of the adventitial VV in the AAA sac; further, immunohistological studies revealed proliferation of smooth muscle cells, which caused luminal stenosis of the VV. We also found decreased HemeB signals in the aortic wall of the sac as compared with those in the aortic wall of the neck region in AAA. The stenosis of adventitial VV in the AAA sac and the malperfusion of the aortic wall observed in the present study are new aspects of AAA pathology that are expected to enhance our understanding of this disease.

• 出版日期2013-2-27