Analysis of familial incidence of non-syndromic cleft lip and palate in a Brazilian population

作者：Martelli Daniella Reis; Bonan Paulo Rogerio Ferreti^*; Soares Matheus Carvalho; Paranaiba Livia Ribeiro; Martelli Junior Hercilio

来源：Medicina Oral, Patologia Oral y Cirugia Bucal, 2010, 15(6): E898-E901.

DOI：10.4317/medoral.15.e898

• Cleft palate
• cleft lip
• epidemiology

Background: The purpose of this study is to follow the familial incidence of non-syndromic or isolated cleft lip, with or without cleft palate (NSCL/P), and to analyze the relationships between the type of NSCL/P in the affected individual and his/her parent, looking at children in the first grade.
Material and Methods: To investigate the familial incidence of NSCL/P we analyzed the records of 185 patients from 2004-2008, retrospectively. Detailed histories were collected regarding the familial incidence of NSCL/P. For the 185 individuals, the relationship between the type of NSCL/P and the sociodemographic and personal characteristics of the affected person and her/his cleft relatives was obtained.
Results: The individuals were 42 carriers of CL, 109 with CLP (joined in one group) and 34 with CP (p<0.001). Of the total of participants, 65 (35.13%) presented a positive history of cleft in their families and 120 (64.86%) presented a negative history (p<0.001). There were differences between the cleft groups according to types of cleft and positive familial history (p<0.001). In both groups, the relatives with higher incidence of NSCL/P were cousins, with the same pattern of distribution between the two groups (p=0.175).
Conclusions: Most frequently, fissures result from CL/CLP with no familial history. However, CL/CLP was found in familial cases and cousins were the relative type more likely to be affected.

• 出版日期2010-11