A novel guluronate oligomer improves intestinal transit and survival in cystic fibrosis mice

作者：Vitko Megan^*; Valerio Dana M; Rye Philip D; Onsoyen Edvar; Myrset Astrid H; Dessen Arne; Drumm Mitchell L; Hodges Craig A

来源：Journal of Cystic Fibrosis, 2016, 15(6): 745-751.

DOI：10.1016/j.jcf.2016.06.005

• Cystic fibrosis
• Intestinal transit
• Mucus
• Genetically modified mouse

Background: Cystic fibrosis (CF) patients experience intestinal complications characterized by the accumulation of thick viscous mucus. CF mice were utilized to determine if a novel guluronate oligomer, OligoG, may be a potential therapy in reducing intestinal mucus and subsequent CF-related intestinal manifestations.
Methods: Intestinal transit, intestinal histology, survival and growth were examined in wildtype and CF mice on regular water and OligoG.
Conclusions: OligoG improves intestinal transit and survival in CF mice by reducing the accumulation of intestinal mucus. OligoG's ability to directly bind mucin, disrupt mucin interaction and/or sequester calcium allowing for mucin expansion may explain the decrease in mucus accumulation.

• 出版日期2016-11